Quantification of the Contributions to Amide Proton Transfer (APT) Contrast
Zhongliang Zu 1 , Hua Li 1 , Junzhong Xu 1 , Daniel F Gochberg 1 , and John C Gore 1
Vanderbilt University, Nashville, TN, United
Amide proton transfer (APT) imaging has been
increasingly applied to several pathologies, and new
variants of APT imaging have been also proposed.
However, APT contrast in practice depends on multiple
experimental and sample parameters, especially for in
vivo applications. Its specificity to amide-water
exchange effects is not clear in many cases. Here, we
systematically studied contributions to APT contrast
separately through simulations and provide criteria for
CEST researchers to evaluate the specificity of new APT
imaging methods and guide interpretation of contrast
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