Abstract #3318
A comparison of iopromide and iopamidol, two acidoCEST MRI contrast agents that measure tumor extracellular pH
Brianna F. Moon 1 , Liu Qi Chen 2 , Peilu Liu 2 , Christine M. Howison 1 , Kyle M. Jones 1 , and Mark D. Pagel 1,2
1
Department of Biomedical Engineering,
University of Arizona, Tucson, Arizona, United States,
2
Department
of Chemistry & Biochemistry, University of Arizona,
Tucson, Arizona, United States
AcidoCEST MRI contrast agents (CA) iopromide
(UltravistTM, Bayer Health Care, Inc.) and iopamidol
(IsovueTM, Bracco Imaging, Inc.) show similar imaging
characteristics with respect to excitation pulse, method
of frequency encoding, and effects CA concentration, T1
time , and temperature. Iopromide shows better CEST
dynamic range for measuring pH, while iopamidol shows
better precision. Both contrast agents can be used to
measure extracellular pH in vivo.
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