Selective Detection of Chemical Exchange Specific R1 by iTIP gagCEST
Wen Ling 1 , Francesca J. Nicholls 1,2 , Tao Jin 1 , Rob Hartman 3 , Nam Vo 3 , Gwendolyn Sowa 3 , James Kang 3 , Michel Modo 1 , and Kyongtae Ty Bae 1
Dept. of Radiology, UPMC, Pittsburgh, PA,
of Neuroscience, Kings College London, London, United
of Orthopaedic Surgery, UPMC, Pittsburgh, PA, United
The implementation iTIP gagCEST on cartilaginous tissue
has been simulated, and experimentally conducted on
phantoms and a rabbit disc. The results from simulation
and phantom have clearly demonstrated that iTIP gagCEST
can quantitatively measure chemical exchange specific
R1 that linearly increases with PG concentration.
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