Abstract #3348
Glioblastoma Vessels Abnormality Quantification in TOF-MRA
Maddalena Strumia 1,2 , Wilfried Reichardt 1,2 , Irina Mader 3 , Jergen Hennig 2 , and Michael Bock 2
1
Deutsches Konsortium fr translationale
Krebsforschung (DKTK), German Cancer Research Center (DKFZ),
Heidelberg, Germany,
2
Department
of Radiology Medical Physics, University Medical Centre,
Freiburg, Germany,
3
Department
of Neuroradiologie, University Medical Centre, Freiburg,
Germany
The glioblastoma is one of the most malignant and
aggressive tumors of the white brain matter, and it
expressing vascular endothelial grow factors (VEGF) to
initiate and maintain angiogenesis. To assess whether a
novel therapeutic drug inhibits neo-angiogenesis,
non-invasive imaging methods to study changes of the
neo-angiogenic vasculature are urgently needed. In this
work we propose new post-processing strategies to
quantify the structure of the pathological vessels in
glioblastomas using TOF-MRA data. The approach has been
applied on 9 glioblastoma patients and showed high
discriminability between tumor vessels and normal brain
vasculature.
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