The Effect of Intravenous Gadolinium on Diffusion Kurtosis Imaging: Evaluation of Brain Tumors
Masaki Katsura 1,2 , Yuichi Suzuki 2 , Junichi Hata 2 , Hiroki Sasaki 1 , Harushi Mori 1 , Akira Kunimatsu 1 , Jian Xu 3 , Katsuya Maruyama 4 , and Kuni Ohtomo 1
Radiology, Graduate School of Medicine, The
University of Tokyo, Bunkyo, Tokyo, Japan,
The University of Tokyo Hospital, Bunkyo, Tokyo, Japan,
Healthcare USA, New York, United States,
Healthcare Japan, Tokyo, Japan
Diffusional kurtosis imaging (DKI) characterizes
non-Gaussian water diffusion behavior. The principal
metric derived from DKI is mean kurtosis (Kmean), which
is thought to be an index of microstructural complexity.
In the current study on clinical cases with brain
tumors, Kmean did not change significantly after
administration of gadolinium-based contrast material.
Our results indicate that DKI can be repeated after
gadolinium-enhanced MR studies. Therefore, when motion
is detected on the initial DK scan or when repeated DKI
images with different imaging techniques are needed,
they can be performed after gadolinium-enhanced imaging
without a significant change in Kmean.
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