Abstract #3359
Neuroanatomy Reveals Radiation-Induced Memory Deficits in Mice
A. Elizabeth de Guzman 1,2 , Benjamin Turnbull 1 , Rebecca Crosier 1 , and Brian J. Nieman 1,2
1
Mouse Imaging Centre, Hospital for Sick
Children, Toronto, Ontario, Canada,
2
Department
of Medical Biophysics, University of Toronto, Toronto,
Ontario, Canada
Therapeutic cranial irradiation for pediatric patients
often results in long term cognitive side effects, such
as memory loss. Using anatomical analysis, we identified
a correlation between memory function, as determined by
the novel object test, and a subset of brain structures
in the young irradiated mouse. Structures identified are
those previously shown to be important in novel object
recognition, demonstrating the potential for
neuroanatomy to act as a marker of cognitive deficit in
the described mouse model.
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