Differentiating Multiple Sclerosis and Neuromyelitis Optica using Myelin Water Imaging and Paired Pulse Transcranial Magnetic Stimulation
Praveena Manogaran 1 , Irene Vavasour 2 , Michael Borich 3 , Shannon Heather Kolind 1 , William Donald Regan 4 , Alex MacKay 2,5 , Lara Boyd 3 , David K. B. Li 2 , and Anthony Traboulsee 1
Medicine, University of British Columbia,
Vancouver, British Columbia, Canada,
University of British Columbia, Vancouver, British
Therapy, Brain Behaviour Lab, Vancouver, British
University of Alberta, Edmonton, Alberta, Canada,
& Astronomy, University of British Columbia, Vancouver,
British Columbia, Canada
This preliminary study aimed to characterize differences
in cortical excitability and myelin status of descending
motor output pathways and evaluate the relationships
between these measures in MS, NMO and controls.
Structural changes were found in the descending motor
output pathway white matter in NMO and cortical
excitability changes in MS that are specific to
intracortical inhibitory pathways in comparison to one
another and also compared to healthy controls. However,
these metrics are not related to one another. These
results suggest that there are both neurophysiological
and neuroanatomical changes that may potentially offer
novel biomarkers to distinguish MS from NMO.
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