Towards Pathoneurochemical Profiling of Multiple Sclerosis: Single-Session Measurement of Glutathione, GABA and Glutamate with MR Spectroscopy at 7 Tesla
Hetty Prinsen 1 , Robin A de Graaf 1 , Graeme F Mason 1 , Daniel Pelletier 1 , and Christoph Juchem 1
Yale University, New Haven, CT, United
Glutathione (GSH), GABA, and glutamate are assumed to
play key roles in the onset and progression of multiple
sclerosis (MS). We report their measurement in a single
1-hour session establishment of J-difference editing and
STEAM MR spectroscopy (MRS) twice in five healthy
individuals and once in an MS patient (along with other
MS-relevant neurochemicals such as NAA, myo-inositol, creatine, and cholines). The implementation is expected
to serve as a tool for clinical MS research, patient
monitoring, and treatment control.
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