Abstract #3379
Effect of affected / unaffected eye viewing on visual cortex GABA - fMRI correlation in patients with optical neuritis
Pallab K Bhattacharyya 1 , Blessy Mathew 1 , Bharath Atthe 1 , Mark Lowe 1 , and Robert Bermel 1
1
Cleveland Clinic, Cleveland, OH, United
States
Increased task-related cortical activation in multiple
sclerosis (MS) has been reported to be correlated with
gamma amino butyric acid (GABA) level in sensorimotor as
well as visual cortex. This has been attributed to
possible role of GABA in cortical adaptation in MS. We
studied 8 MS patients with optical neuritis to
investigate whether the impairment of specific eye has
any effect on the correlation of GABA with activation.
We observe that the correlation is independent of the
impairment of the eye suggesting potential role of GABA
in cortical adaptation is a general phenomenon in MS.
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