Total sodium quantification of the cervical cord in multiple sclerosis
Bhavana Shantilal Solanky 1 , Frank Riemer 1 , Xavier Golay 2 , Olga Ciccarelli 2 , and Claudia AM Wheeler-Kingshott 1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, United Kingdom
A careful balance of intra- and extracellular sodium
exists in healthy tissue. In multiple sclerosis (MS)
sodium imbalances in brain lesions, as well as in normal
appearing white matter have been reported. It is thought
that this could be due to increased extracellular space,
and/or an increased intracellular sodium accumulation.
The low SNR of sodium-MRI and the small size of the
spinal cord has made quantification in spinal cord
challenging. Here we have quantified spinal cord sodium
in MS patients for the first time using the recently
FUSS ISIS sequence.
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