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Abstract #3404

Altered Microstructure of Normal Appearing White Matter in Multiple Sclerosis: Association with Neurological Disability

Maria Vittoria Spampinato 1 , Meaghan Neill 1 , Neal Hatch 1 , Jens H. Jensen 2 , Joseph Helpern 2 , and Ali Tabesh 2

1 Medical University of South Carolina, Charleston, SC, United States, 2 Medical University of South Carolina, SC, United States

We assessed correlations between measures of brain tissue microstructure derived from diffusional kurtosis imaging and neurological disability in forty-one patients with multiple sclerosis. We found significant correlations between the Expanded Disability Status Scale (EDSS) and diffusion metrics of the normal appearing white matter of the entire skeleton, genu and body of the corpus callosum, and cortico-spinal tracts. Quantitative imaging metrics may prove useful as predictors of clinical outcome in multiple sclerosis and have the potential to guide treatment.

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