Brain Diffussivity and Neurochemical Changes in Obstructive Sleep Apnea: A Pilot Correlation Study
Manoj Kumar Sarma 1 , Rajakumar Nagarajan 1 , Paul Michael Macey 2 , Ravi Aysola 3 , and M. Albert Thomas 1
Radiological Sciences, UCLA School of
Medicine, Los Angeles, CA, United States,
of Nursing, UCLA School of Medicine, Los angeles, CA,
of Pulmonary and Critical Care Medicine, UCLA School of
Medicine, Los Angeles, CA, United States
Obstructive sleep apnea (OSA) is a common disorder
characterized by repeated hypoxic episodes during sleep.
Cerebrovascular risk factors such as hypertension,
diabetes mellitus, obesity can be offshoot of OSA.
Advanced neuroimaging techniques, such as diffusion
tensor imaging (DTI) and magnetic resonance
spectroscopic imaging (MRSI) enable non-invasive and
accurate identification of OSA-induced, structuralneurochemical
changes. The goals of this study were to investigate
changes in FA and MD between OSA patients and healthy
controls and correlate the FA /MD values with metabolite
ratios in various brain regions of OSA patients.
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