Functional-structural relationship in the cervical spinal cord: application to multiple sclerosis
Moreno Pasin 1 , Marios Yiannakas 1 , Hugh Kearney 1 , Ahmed Toosy 2 , and Claudia A. M. Wheeler-Kingshott 1
NMR Unit, Department of Neuroinflammation,
UCL, Institute of Neurology, London, United Kingdom,
of Brain Repair and Rehabilitation, UCL, Institute of
Neurology, London, United Kingdom
We investigated correlations between functional and
diffusion data in the spinal cord in patients affected
by Multiple Sclerosis. Four healthy controls and four MS
patients participated in this study. Sensory stimulus
was applied and activations were found in all subjects.
Greater lateralization index (LI) in MS patients was
significantly associated with lower posterior column
white matter fractional anisotropy (PCWM-FA) and higher
EDSS. Controls did not show a significant relation
between LI and PCWM-FA. PCWM-FA showed less variance in
controls than MS patients. This pilot study reports
significant correlations between fMRI and diffusion
data, albeit with small sample sizes.
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