Age Dependence of Brain Bioenergetics in Bipolar Disorder
Jonathan Dudley 1,2 , James Eliassen 1,2 , Elizabeth Fugate 2 , Wen-Jang Chu 1,2 , and Jing-Huei Lee 1,2
Department of Psychiatry and Behavioral
Neuroscience, University of Cincinnati, Cincinnati,
Ohio, United States,
for Imaging Research, University of Cincinnati,
Cincinnati, Ohio, United States
The gray mater (GM) bioenergentic metabolisms in
patients with bipolar disoder (BD) were investigated.
Tissue regression analysis of 31P MRSI data was
performed based on tissue contents that were obtained by
SPM5 segmentation of MDEFT images. The results showed
that dependence on age was significantly different in GM
between BD and healthy control groups for concentrations
of inorganic phosphate (p = 0.0032), phosphocreatine (p
= 0.0029), and adenosine triphosphate (p = 0.0176). This
implies that neuronal bioenergetic abnormality increases
in severity with duration of illness.
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