MRI Detection and Histological Correlates of the Dependence of Brain Damage on Recovery Time Between Recurrent Mild Strokes.
Qinbo Deng 1 , Min Qiao 2 , Tadeusz Foniok 3 , Dave Rushforth 3 , and Ursula I Tuor 2,4
University of Calgary, Calgary, Alberta,
and Pharmacology, University of Calgary, Alberta,
Imaging Centre, University of Calgary, Alberta, Canada,
Neurosciences and Radiology, University of Calgary,
Recovery from an initial mild ischemic insult could
influence the susceptibility of the brain to a second
insult. We assessed brain damage using magnetic
resonance imaging and histology comparing brain damage
produced by a combination of two mild transient ischemic
insults with intervals of either 1 day, 2 day, 3 day or
1 week. A recurrent mild PT enhanced the tissue damage
and this enhancement was greater with a short recovery
(1-3d) versus a longer recovery (1w) between insults.
This indicates that brain is most susceptible to a
second mild ischemic insult for several days after a
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