Abstract #3489
A Novel Mouse Model of Vascular Cognitive Impairment A Diffusional Kurtosis Imaging Study
Edward S Hui 1 and Andy Y Shih 2
1
The University of Hong Kong, Pokfulam, Hong
Kong, Hong Kong,
2
Medical
University of South Carolina, Charleston, South
Carolina, United States
Cerebral small vessel disease (SVD) is frequently found
in patients with vascular dementia and Alzheimers
disease. Microinfarcts are hallmarks of SVD, and their
gradual accumulation in the brain is strongly correlated
with cognitive impairment. Microinfarcts may be useful
biomarkers for early detection of cognitive decline. The
objective of this study is to investigate spatiotemporal
changes in MRI signals associated with murine
microinfarcts using DKI. Our preliminary results
indicate that microinfarcts are only visible over a
short duration (3 days) after vascular occlusion.
Methods to prolong and enhance the visibility of
microinfarcts will be useful to improve detection in
humans.
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