Nootropics prevent the effect of scopolamine in an phMRI provocation model
Nikolett Hegeds 1 , Pl Kocsis 2 , Dvid Gajri 2 , Szabolcs Dvid 2 , Levente Deli 2 , Zsfia Pozsgay 2 , and Kroly Tihanyi 2
Gedeon Richter Plc., Budapest, Hungary,
Richter Plc., Hungary
The effective treatment of cognitive decline is still a
major challenge of the drug research. Scopolamine based
small animal phMRI provocation model can be a suitable
translational method for testing new compounds.
Scopolamine strongly decreased the BOLD responses in the
PFC but had no visible effect in other brain areas.
Scopolamines effect could be fully prevented with the
donepezil pretreatment, whereas vinpocetin and piracetam
caused a partial reversal of the BOLD responses only.
The new vinpocetin derivative RG compound exerted
partial effect also, but its effective dose was much
lower than that of the reference compound donepezil.
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