Mapping Gd-DOTA leakage kinetics in experimental cerebral malaria
Teodora-Adriana Perles-Barbacaru 1 , Emilie Pecchi 1 , Monique Bernard 1 , Patrick J Cozzone 1 , and Angele Viola 1
CRMBM UMR CNRS 7339, Aix Marseille
University, Marseille, France
Increased permeability of the blood-brain barrier has
been suggested as one of the pathophysiological
mechanisms in cerebral malaria, an encephalopathy caused
by Plasmodium infection. Here, we quantified the spatial
and temporal occurrence of endothelial permeability to
Gd-DOTA in vivo during progression to cerebral malaria
in a mouse model using dynamic MRI at 11.75T. Abnormal
permeability appeared simultaneously with the first
clinical signs and was quantitatively related to their
severity. Spatial differences were observed with
olfactive regions displaying the highest permeability.
Quantitative mapping of the endothelial permeability by
MRI can be used for follow-up and treatment monitoring.
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