Measurement of white matter maturation in the preterm brain using NODDI.
Zach Eaton-Rosen 1 , Andrew Melbourne 1 , Alan Bainbridge 2 , Giles S. Kendall 3 , Nicola J. Robertson 3 , Neil Marlow 3 , and Sebastien Ourselin 1
CMIC, UCL, London, United Kingdom,
Physics, UCH, London, United Kingdom,
Neonatology, EGA UCL Institute for Women's Health,
London, United Kingdom
Very preterm infants are more likely to suffer from
neurodevelopmental disabilities, associated with white
matter damage. Diffusion tensor parameters can infer
damage but with limited specificity to the
microstructure. We used multi-shell diffusion MR on a
longitudinal preterm neonatal cohort to fit the NODDI
model and separated diffusion parameters into
contributions from orientation dispersion (OD) and from
the intra-cellular volume fraction (v
found that the increasing FA in white matter regions is
attributable to an increasing v
OD remains constant. This work will help to establish
parameterized growth rates in key white matter regions
in the preterm brain.
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