In vivo MRI evidence of cranial nerve inflammation after corneal damage
Linda Chaabane 1 , Fabio Bignami 2 , Chiara Giacomini 2 , Eleonora Capitolo 1 , Paolo Rama 2 , Giulio Ferrari 2 , and Giancarlo Comi 1
INSPE, Div. Neuroscience, San Raffaele
Scientific Institute, Milano, Italy,
and Ocular Surface Unit, San Raffaele Scientific
This study was designed to put in evidence the
inflammatory activity within a cranial nerve, the
trigeminal ganglion, induced by a peripheral damage of
the cornea. In vivo MRI in combination with uspio
contrast allowed the evidence of uspio uptake in the
trigeminal ganglion far away from the site of injury
(cornea) which correlated to specific inflammatory cells
positive to immuno-markers of M2 macrophages.
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