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Abstract #3541

Quantitative Gadolinium-based Aerosol Deposition and Dynamics in Healthy Rat Lung by UTE-MRI

Hongchen Wang 1 , Catherine Sbri 1 , Jean-Pierre Ruaud 1 , Genevive Guillot 1 , Khaoula Bouazizi-Verdier 1 , Georges Willoquet 1 , Xavier Matre 1 , Luc Darrasse 1 , and Ludovic de Rochefort 1

1 Imagerie par Rsonance Magntique Mdicale et Multi-Modalits (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Orsay, France

Aerosol toxicology and drug delivery through the lungs require the development of methods to quantify particle deposition. The use of intrapulmonary-administered MRI contrast agent combined to lung-specific imaging sequences has been proposed and remains an active preclinical research topic. Various administration protocols and pulse sequences have been used, and more recently ultra-short echo (UTE) sequences that are more adapted for lung parenchyma imaging. Here, we present the use of 3D UTE implemented in a clinical scanner, performed pre- and post- administration of gadolinium-based aerosol delivery in spontaneously breathing healthy rats, thus mimicking chronic particle exposure or free-breathing drug delivery. The contrast-enhanced quantification method enabled us to follow up lung clearance and regional heterogeneity in the deposition.

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