Abstract #3550
A quantitative technique for assessing the temporal dynamics of regional specific ventilation in response to methacholine challenge in asthma using oxygen enhanced proton MRI
Rui Carlos S 1 , Amran K Asadi 1 , Rebecca J Theilmann 2 , and G. Kim Prisk 1,2
1
Medicine, University of California, San
Diego, La Jolla, CA, United States,
2
Radiology,
University of California, San Diego, La Jolla, CA,
United States
Asthma is a dynamic disease that possesses strong,
poorly understood temporal components. We describe an
improved analysis of Specific Ventilation Imaging - a
quantitative oxygen-enhanced MR-technique - that may be
useful in elucidating time-varying ventilation
heterogeneity after acute asthma events. Specific
ventilation is quantified by comparing the modeled
response of ideal lung units with individual voxel
signal intensity time-series, following changes from
breathing air to oxygen. Temporal changes are captured
using an overlapping running window (120 breaths, 600s,
shifted by 200s). Regional ventilation is seen to
recover towards baseline over time following
bronchoconstriction of a mild asthmatic subject with
methacholine.
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