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Abstract #3556

The effect of renal denervation on renal oxygenation as measured on BOLD MRI

Anneloes de Boer 1 , Eva E Vink 2 , Tim Leiner 3 , Peter J Blankestijn 2 , and Hans M Hoogduin 3

1 Nephrology, University Medical Center, Utrecht, Utrecht, Netherlands, 2 Nephrology, University Medical Center, Utrecht, Netherlands, 3 Radiology, University Medical Center, Utrecht, Netherlands

Renal denervation (RD) is a promising new therapy for resistant hypertension. The mechanism of action is proposed to be a decrease in sympathetic activity, resulting in altered sodium handling by the kidneys and a decrease in peripheral vascular resistance. As a consequence, one can hypothesize that renal blood flow and oxygenation will increase. To assess changes in oxygenation in the kidney after RD, BOLD MRI was performed in 38 patients before and 12 months after RD. Data were analyzed using the compartmental method of Ebrahimi et al. No change in renal oxygenation was demonstrated.

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