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Abstract #3561

Renal Perfusion by ASL is Associated with GFR in Long-term Survivors of Wilms Tumor

Ruitian Song 1 , Ralf B. Loeffler 1 , Aaryani Tipirneni-Sajja 1 , Adam M. Winchell 1 , Mary B McCarville 1 , Melissa M. Hudson 2 , Sheri L. Spunt 2 , and Claudia M Hillenbrand 1

1 Radiological Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, United States, 2 Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, United States

ASL MRI was applied to investigate renal perfusion irradiated and non-irradiated long-term survivors of Wilms tumor and in healthy volunteers. Between survivors no significant differences were observed in cortical and medullary blood flow (CBF and MBF), and glomerular filtration rate (GFR). MBF values of survivors were significantly higher than those of healthy volunteers. Normalized CBF and MBF were well correlated with absolute GFR.

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