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Abstract #3563

Intra-tumoral Heterogeneity in Tumor Vascularity Correlates with ADC Quantification in Renal Masses

Qing Yuan 1 , Koji Sagiyama 2 , Yue Zhang 1 , Naira Muradyan 3 , Annanth Madhuranthakam 1,2 , Yin Xi 1 , Ivan E Dimitrov 2,4 , Vitaly Margulis 5 , James Brugarolas 6,7 , Payal Kapur 5,8 , and Ivan Pedrosa 1,2

1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3 iCAD, Inc., Nashua, NH, United States, 4 Philips Medical Systems, Cleveland, OH, United States, 5 Urology, UT Southwestern Medical Center, Dallas, TX, United States, 6 Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 7 Developmental Biology, UT Southwestern Medical Center, Dallas, TX, United States, 8 Pathology, UT Southwestern Medical Center, Dallas, TX, United States

The purpose of this study is to investigate the correlation between the in vivo heterogeneity in tumor perfusion and cellularity in renal masses using dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) techniques. Quantitative DCE and DWI parameters were obtained from the whole tumor, and from areas with high- and low-enhancement in the tumor. High-enhancement tumor regions demonstrated significant higher perfusion measures as well as lower ADC values. Our results confirm the correlation between intra-tumoral heterogeneity in blood flow and ADC in patients with renal masses.

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