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Abstract #3569

ASL and BOLD MRI Measurements in Human Kidneys

Jon Thacker 1 , Huan Tan 2 , Lu-Ping Li 3,4 , Wei Li 3 , Stuart Sprague 4,5 , Orly Kohn 6 , Ivana Lazich 6 , and Pottumarthi V Prasad 3,4

1 Northwestern University, Evanston, IL, United States, 2 Department of Surgery, University of Chicago, IL, United States, 3 Department of Radiology, Northshore University HealthSystem, IL, United States, 4 The University of Chicago Pritzker School of Medicine, IL, United States, 5 Division of Nephrology, Northshore University HealthSystem, IL, United States, 6 Section of Nephrology, The University of Chicago Pritzker School of Medicine, IL, United States

In this study we sought to assess if there was a correlation between arterial spin labeled perfusion and blood oxygen level dependent oxygenation measurements in healthy subjects and patients with chronic kidney disease (CKD). We found that there was no significant correlation between the two, suggesting that, unlike most organs, renal oxygenation is not determined by blood flow. Additionally we found a significant R2* change in healthy subjects renal medulla between baseline and furosemide challenge. No significant change in R2* was observed in other regions or CKD patients.

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