MRI based Noninvasively Differentiation between Aggregated and Dispersed Liver Iron in vivo: a feasibility study
Arthur Peter Wunderlich 1 , Markus Juchems 1 , Holger Cario 2 , Matthias Weigel 3 , and Meinrad Beer 1
Dept. for Diagnostic and Interventional
Radiology, Univ.-Clinic Ulm, Ulm, Germany,
Univ.-Clinic Ulm, Ulm, Germany,
Physics, University of Basel Hospital, Basel,
A method previously described by Jensen et al. was
implemented and tested in a clinical setting. 20
patients suspected for liver iron overload were scanned
by MRI using spin-echo (SE) and multi-contrast spin-echo
(MC-SE) sequences. Data of MC-SE were fitted to theory
to get tissue parameters which are hypothesized to allow
a differentiation between aggregated and dispersed liver
iron. The two parameters in question were correlated to
liver iron content (LIC) determined from SE sequences.
Only the aggregation index A correlated positively to
LIC. The other parameter reduced transverse relaxation
rate RR2 showed no significant correlation to LIC.
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