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Abstract #3597

Signal Intensity Ratio between Liver and Muscle Reference in Highly Iron Overloaded Patients: comparing 1.5 T to 3 T

Arthur Peter Wunderlich 1 , Steffen Klmpken 1 , Holger Cario 2 , Markus Juchems 1 , and Meinrad Beer 1

1 Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2 Pediatry, Univ.-Clinic Ulm, Ulm, Germany

The liver of highly iron overloaded patients was scanned with breathhold GRE sequences at 1.5 T and 3 T. To address high liver iron content (LIC), we measured the signal intensity ratio (SIR) between liver and paraspinal muscle serving as reference. In theory, logarithm of these SIR values are expected to depend linearly on R 2 * difference between liver and muscle tissue which itself varies with LIC due to R 2 * changes with iron deposition in the liver. Dependence of SIR on LIC was evaluated and results compared between field strengths.

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