Abstract #3608
Pancreas fat via Dual-Echo mDIXON Imaging shows that Intracellular Fat does not Accumulate within the Pancreas of Healthy and T2DM Subjects
Paul Begovatz 1 , Chrysi Koliaki 1 , Julia Szendroedi 1 , Guido Giani 2 , Juergen Bunke 3 , and Michael Roden 1,4
1
Institute for Clinical Diabetology, German
Diabetes Center, Leibniz Center for Diabetes Research at
Heinrich Heine University, Duesseldorf, Germany,
2
Institute
for Biometry and Epidemiology, German Diabetes Center,
Leibniz Center for Diabetes Research at Heinrich Heine
University, Germany,
3
Philips
Healthcare, Hamburg, Germany,
4
Department
of Endocrinology and Diabetology, University Clinics,
Heinrich Heine University, Duesseldorf, Germany
Pancreatic steatosis has been linked to -cell
dysfunction in the development of type 2 diabetes
(T2DM). However,
1
H-MRS
and MRI studies investigating pancreatic fat and -cell
function have shown conflicting results. In this work,
mDIXON imaging with a noise reduction fat fraction
algorithm was verified in comparison to
1
H-MRS
liver fat measurements. Pancreas fat was then measured
in 48 participants: lean, overweight/obese, and T2DM.
Results showed that avoiding regions of interlobular fat
revealed clear regions of parenchymal tissue void of any
lipid accumulation. These results show for that the
pancreas does not consist of intracellular fat leading
to pancreatic steatosis.
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