MR Elastography for the Assessment of Hepatic Fibrosis in Patients with Chronic Hepatitis B: Does Histological Necroinflammation Influence the Measurement of Liver Stiffness?
Yu Shi 1,2 , Qiyong Guo 1 , Fei Xia 3 , Bogdan Dzyubak 2 , Kevin J. Glaser 2 , and Richard L. Ehman 2
Department of radiology, Shengjing hospital,
Shenyang, Liaoning, China,
Clinic, Rochester, MN, United States,
of infectious diseases, Shengjing hospital, Shenyang,
MRE had a high diagnostic accuracy for hepatic fibrosis
in chronic hepatitis B. Both fibrosis stage and
necroinflammation grade were independent factors
contributing to liver stiffness (Multivariate linear
regression, =0.798, 0.275; P< .001). For liver tissue
with F2 fibrosis, necroinflammation accounts for a
portion of the elevated liver stiffness.
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