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Abstract #3658

Detecting CA-lys-TFA a synthetized novel trifluorinated bile acid in murine gallbladder using in vivo 19 F MRI

Su Xu 1,2 , Diana Vivian 3 , Kunrong Cheng 4 , Sandeep Khurana 4 , Wenjun Zhu 1,2 , Andrew Marshall 1,2 , Rao Gullapalli 1,2 , James Polli 3 , and Jean-Pierre Raufman 4

1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Core for Translational Research in Imaging @ Maryland, Baltimore, MD, United States, 3 Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States, 4 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Using in vivo 19 F MRI, a novel synthesized trifluorinated bile acid CA-lys-TFA was tested for its ability to concentrate in the gallbladders of C57BL/6 mice after oral gavage. Mice orally gavaged with 19 F labled CA-lys-TFA revealed robust 19 F signals from the gallbladder in vivo , and correlated with the concentrations determined independently using LC-MS on ex vivo tissue. The results from the study suggest that CA-lys-TFA, a fluorinated non-radioactive bile acid analogue, has potential for use in MRI to measure in vivo bile acid transport and diagnose bile acid malabsorption and other conditions associated with impaired bile acid transport.

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