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Abstract #3673

Phantom validation of temperature mapping using fat-water MRI with explicit fitting of water peak location

E. Brian Welch 1,2 , Aliya Gifford 2,3 , and Theodore F. Towse 2,4

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, United States, 4 Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, TN, United States

This research demonstrates MRI-based thermometry in fat-water phantoms by explicitly modeling the temperature-dependent water peak frequency shift in the fat-water signal equation. Besides temperature monitoring of mixed fat/water tissue during interventional applications, this method is well suited for studying brown adipose tissue. The technique was tested on phantoms with nominal fat fractions of 0, 10, 20, 30, 40, 60 and 100 percent undergoing heating and cooling with validation using fiber optic temperature probes. MRI-based measurements followed closely the probe measurements except for areas with fat-water mapping errors or in phantoms with only one species, i.e. 0% or 100% fat.

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