Sensitivity and specificity to quantify changes in human brain glutathione and ascorbate concentrations using short echo-time 1 H MRS at 3 T and 7 T
Dinesh K Deelchand 1 , Malgorzata Marjanska 1 , and Melissa Terpstra 1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States
We determined the accuracy and precision to measure GSH
and Asc concentrations in ultra-short echo time spectra
when injecting phantom measured GSH and Asc spectra into
5 in vivo human brain spectra acquired at 3 T and 7 T.
We found that a change in GSH ≥ 40% is detectable at
both fields while a change in Asc can only be quantified
at 7 T.
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