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Abstract #3740

Long-term reproducibility of GABA levels in the occipital cortex of healthy volunteers

Jamie Near 1 , Yi-Ching Lynn Ho 2 , Kristian Sandberg 3,4 , Chathura Kumaragamage 5 , and Jakob Udby Blicher 6

1 Department of Psychiatry, McGill University, Montral, Qubec, Canada, 2 Department of Clinical Medicine - Diagnostic Radiology, Aarhus University, Aarhus, Aarhus, Denmark, 3 Cognitive Neurosciences Research Unit, Aarhus University Hospital, Aarhus, Aarhus, Denmark, 4 UCL Institute of Cognitive Neurosciences, University College London, London, London, United Kingdom, 5 Biomedical Engineering, McGill University, Montral, Qubec, Canada, 6 CFIN, Aarhus University Hospital, Aarhus, Aarhus, Denmark

In this study, we investigated the long-term reproducibility of MEGA-PRESS edited magnetic resonance spectroscopy measurements of GABA in the occipital cortex of 19 healthy male volunteers. Repeated measurements were performed over a period of seven months; a much longer interval than previous GABA reproducibility studies in the literature, which used intervals of eight days or less. Across all subjects, the average coefficient of variation for repeated measurements was 5.5%, which is similar to the findings of short-term reproducibility studies. These results suggest that GABA concentrations in the occipital cortex are stable over relatively long periods of time.

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