Meeting Banner
Abstract #3759

Metabonomics of Celiac Disease by in-vitro Proton NMR Spectroscopy of Blood Plasma

Deepti Upadhyay 1 , Naranamangalam R Jagannathan 1 , Uma Sharma 1 , Govind Makharia 2 , Prasenjit Das 3 , and Siddhartha Datta Gupta 3

1 Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, 2 Department of Gastroeneterology, All India Institute of Medical Sciences, New Delhi, Delhi, India, 3 Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Celiac disease (CeD) is an autoimmune enteropathy caused by ingestion of gluten and related prolamines present in cereals like wheat, rye, and barley in genetically predisposed individuals. Proton NMR based metabonomics of blood plasma of CeD patients showed higher concentration of glucose, acetoacetate, alanine and glycine compared to controls which may be due to alteration in energy metabolism. Blood plasma of CeD patients were also characterized by higher level of glutamine suggesting its involvement in pathogenesis. Decreased concentration of creatinine is observed in blood plasma of CeD patients in comparison to controls. This may be due to protein malabsorption.

This abstract and the presentation materials are available to members only; a login is required.

Join Here