TO DIFFERENTIATE GLUTAMINE FROM GLUTAMATE IN HEPATIC ENCEPHALOPATHY BY TWO-DIMENSIONAL (2D) LOCALIZED CORRELATED SPECTROSCOPY (L-COSY) COMBINED WITH PROFIT QUANTITATION
Rajakumar Nagarajan 1 , Manoj K Sarma 1 , and M.Albert Thomas 1
Radiological Sciences, University of
California Los Angeles, LOS ANGELES, CA, United States
Brain energy metabolism is believed to be disturbed in
cirrhotic patients with hepatic encephalopathy (HE).
Ammonia is a neurotoxin and causes increased conversion
of glutamate to glutamine. Previous work has shown the
important role of MRS in diagnosing and monitoring
patients with metabolic disorders. In the
one-dimensional (1D) proton MRS, it is very difficult to
separate the resonances of glutamate from glutamine and
quite often the two are reported together as Glx. In the
two-dimensional (2D) localized correlated spectroscopy
(L-COSY), additional spectral dimension will be used to
separate the overlapping multiplets. The major goal of
this study is to review the role of 2D-L-COSY combined
with a prior knowledge fitting (ProFit) algorithm in
separating glutamine from glutamate in HE patients.
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