In Vivo 17 O MR Imaging and Quantification of CMRO 2 , CBF and OEF in Human Visual Cortex at Rest and during Activation
Xiao-Hong Zhu 1 , Xiao Liu 1 , Ming Lu 1 , Hannes M Wiesner 1 , Kamil Ugurbil 1 , and Wei Chen 1
CMRR, Department of Radiology, University of
Minnesota Medical School, Minneapolis, MN, United States
MRS/I technique has unique ability for assessing oxygen
oxygen gas inhalation. However, quantification of
cerebral metabolic rate of oxygen (CMRO
human is complicated by the large body size and slow gas
exchange process, which becomes more problematic when a
short inhalation is applied. In this study, a simple
approach was proposed for measuring the gas exchange
rate in the lung, which was incorporated into a
comprehensive quantification model for simultaneous
determination of three important physiology parameters
, CBF and OEF in the human brain.
This new approach was tested in resting and stimulated
human brain. The preliminary results showed similar
resting state CMRO
, CBF and OEF values as
reported in literature; and a large CBF increase (>40%)
in accompany with smaller increases in CMRO
OEF (<20%) were observed in activated visual cortex,
which support the notion of unmatched CMRO
CBF changes in response to a physiological stimulation.
The overall results validate the proposed model and
provide a quantitative neuroimaging tool for noninvasive
, CBF and OEF in healthy and
diseased human brains.
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