Abstract #3767
In vivo 1 H MRS of Dynamic 13 C Labeling of Glutamate and Glutamine
Li An 1 , Shizhe Li 1 , Maria Ferraris Araneta 1 , Christopher Johnson 1 , James B Murdoch 2 , and Jun Shen 1
1
National Institute of Mental Health,
National Institutes of Health, Bethesda, MD, United
States,
2
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
The feasibility of using a proton-only pulse sequence to
measure dynamic glutamate and glutamine labeling process
during infusion of
13
C
labeled glucose at 7T was demonstrated by numerical
simulations and
in
vivo
experiments
on two healthy volunteers. Compared to conventional
proton-observed
13
C-edited
experiments, the proton-only pulse sequence is much
simpler in hardware and software requirements since it
is a pure
1
H
pulse sequence with no RF pulses at
13
C
resonances.
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