Meeting Banner
Abstract #3795

Spectrally Selective Imaging of Hyperpolarized 13 C Pyruvate with Multi-Echo, Multi-Phase Advance Balanced Steady State Free Precession

Gopal Varma 1 , Xiaoen Wang 1 , and Aaron K Grant 1

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Balanced steady-state free precession (bSSFP) offers potential advantages for imaging of hyperpolarized 13 C, including high signal-to-noise ratio (SNR) and efficient use of magnetization. Several variants of bSSFP provide spectroscopically selective images, including multi-echo methods and techniques that use a variable RF phase advance. Both approaches have undesirable sensitivity to off-resonance, and poor conditioning of the reconstruction can degrade SNR. Here we describe a multi-echo variable phase advance method that may provide more robust imaging. The technique is applied to phantoms and in vivo imaging of pyruvate and its metabolites, yielding images with 1mm 2 in-plane resolution, 4mm slice, and peak lactate SNR~30.

This abstract and the presentation materials are available to members only; a login is required.

Join Here