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Abstract #3808

Axonal transport rate decreased at the onset of optic neuritis in EAE mice

Tsen-Hsuan Lin 1 , Joong Hee Kim 2 , Carlos Perez-Torres 2 , Chia-Wen Chiang 2 , Kathryn Trinkaus 3 , Anne H. Cross 4,5 , and Sheng-Kwei Song 2,5

1 Physics, Washington University, St. Louis, MO, United States, 2 Radiology, Washington University School of Medicine, St. Louis, MO, United States, 3 Biostatistics, Washington University School of Medicine, St. Louis, MO, United States, 4 Neurology, Washington University School of Medicine, St. Louis, MO, United States, 5 The Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States

Axonal transport plays a crucial role in neurodegenerative diseases. However, few reports have assessed axonal transport rate in MS or in experimental autoimmune encephalomyelitis (EAE). To assess the integrity of axonal transport in EAE, we employed the widely used manganese-enhanced MRI (MEMRI) on EAE mice at the onset of optic neuritis. Our results reveal that the axonal transport rate in EAE mice at the optic neuritis onset was significant decreased compared with the sham mice and correlated well with severity of impaired visual function. Postmortem immunohistochemistry was performed to assess optic nerve pathologies, including axonal injury, demyelination, and inflammation.

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