In vivo cellular MRI monitoring of FeO Labeled DC-based cancer vaccine for immunotherapeutic treatment of pancreatic cancer
Zhuoli Zhang 1 , Andrew Christian Gordon 1 , Weiguo Li 1 , Yang Guo 1 , Elias Gounaris 1 , Alexander Sheu 1 , Jodi Robin Nicolai 1 , Daniele Procissi 1 , and Andrew Larson 1
Radiology, Northwestern University, Chicago,
Illinois, United States
In this work we demonstrate that iron-oxide labeled
Dendritic Cells (DC), loaded with antigens, can be
effectively tracked as they home in on the lymph nodes
using MRI. We also correlate therapeutic response to
successful targeting of DC as measured with MRI. The
potential of the methods described can provide
additional tools to develop DC based cancer vaccines.
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