In-Vivo Temperature Measurement using ParaCEST MRI Contrast Agents at 9.4T
Nevin McVicar 1,2 , Alex X Li 2 , Mojmir Suchy 3 , Robert H Hudson 3 , and Robert Bartha 1,2
Medical Biophysics, University of Western
Ontario, London, Ontario, Canada,
for Functional and Metabolic Mapping, Robarts Research
Institute, London, Ontario, Canada,
University of Western Ontario, London, Ontario, Canada
Tissue temperature is measured in-vivo in mouse leg
muscle following intramuscular injection of a paraCEST
contrast agent using magnetic resonance imaging (MRI).
Tissue MRI properties including relaxation time
constants, diffusion coefficients and magnetization
transfer effects were measured before and after paraCEST
injection. Significant changes in tissue MR properties
were observed between pre- and post-injection data. Only
apparent diffusion coefficient correlated with measured
tissue temperature. The paraCEST tissue temperature
measurements were in agreement with true tissue
temperature. Therefore, in-vivo tissue temperature
measurements made using paraCEST contrast agents
following direct injection are accurate despite changes
in tissue relaxation properties.
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