Evaluation of the reversibility of the binding between a targeted CA and its receptor by in vitro micro-MRI
Nicolas Gargam 1 , Luc Darrasse 1 , Philippe Robert 2 , Jean-Christophe Ginefri 1 , Jean-Sbastien Raynaud 2 , and Marie Poirier-Quinot 1
IR4M - UMR 8081, Universit Paris Sud XI,
and Biological Research, Guerbet, Paris, France
In this study, we introduce an in vitro set-up that
allows to control the binding of a targeted CA to its
receptor by micro-MRI. Experiments inspired by the
BIAcore system were realized and allowed to know the
kinetics of a CA towards its receptor. This new
technique could help optimizing the in vivo protocols
especially for the optimal time between the injection of
the CA and the imaging acquisition.
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