Abstract #3896
Cardiac Cine MRI for Mice with Myocardial Infarction using 3D Self-gated Radial Gradient Echo
Naoharu Kobayashi 1 , Qiang Xiong 2 , Jing Guo 2 , Jianyi Zhang 2 , and Michael Garwood 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, Minnesota, United
States,
2
Department
of Medicine, University of Minnesota Medical School,
Minnesota, United States
A radial gradient echo sequence with cardiac self-gating
is introduced for 3D cine imaging of mice with
myocardial infarction (MI). Accuracy of the MR
self-gating was validated by comparing with ECG signals.
In order to accelerate 3D acquisition, compressed
sensing reconstruction was applied and predominantly
removed undersampling artifacts and noise, resulting in
reasonable scan time in animal experiments (14 min). The
proposed methods visualized dynamics of cardiac function
for MI mice with various infarct sizes; the 3D
self-gated cine MRI technique is robust for MI mice with
severe arrhythmia associated with significantly adverse
left ventricular remodeling.
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