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Abstract #3909

Delayed gadolinium enhanced MRI reveals nanotherapy-induced normalization of the vessel wall endothelium in atherosclerotic mice

Claudia Calcagno 1 , Jun Tang 1 , Laurien Hassing 1,2 , Brenda L Sanchez-Gaytan 1 , Gustav Strijkers 1,2 , Willem JM Mulder 1,2 , and Zahi A Fayad 1

1 Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2 Amsterdam Medical Center, Amsterdam, The Netherlands, Netherlands

Atherosclerosis is the number one killer world-wide. Increased permeability due to inflammation is a hallmark of vulnerable atherosclerotic plaques, at high-risk of causing myocardial infarction or stroke. This knowledge has spurred interest in developing new compounds to lower plaque inflammation, and non-invasive techniques to quantify their efficacy. Here we examine the effects on vessel wall permeability of a previously developed drug-loaded lipoprotein nanoparticle ([S]-rHDL) with known potent anti-inflammatory effects. We demonstrate that this compound lowers aortic plaque permeability in atherosclerotic ApoE-KO mice, as determined by in vivo Gd-DTPA enhanced MRI, and as validated by ex vivo EB NIRF imaging.

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