Studying the interplay between atherosclerosis and deep vein thrombosis in a murine model using an elastin-binding contrast agent
Alkystis Phinikaridou 1 , Prakash Saha 1 , Marcelo K Andia 2 , Alberto Smith 1 , and Rene M Botnar 1
King's College London, London, United
Universidad Catolica de Chile, Santiago, Chile
Venous thrombosis and atherosclerosis are common
conditions that together cause significant morbidity and
mortality worldwide. Recent evidence suggests that
venous thrombosis increases the risk of myocardial
infarction and stroke, which persists for many years
following the thrombotic event. In the current work, we
sought to use an experimental model of atherosclerosis
and deep vein thrombosis to investigate the link between
plaque growth and venous thrombosis using an elastin-specific
MR contrast agent in a longitudinal fashion.
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