Optimal Sequence Weighting for 3D Dynamic Contrast Enhanced Imaging
Philip M Robson 1 , Claudia Calcagno 1 , Sarayu Ramachandran 1 , Mark E Lobatto 1 , Julia Witjes 1 , Venkatesh Mani 1 , and Zahi A Fayad 1
Translational and Molecular Imaging
Institute, Icahn School of Medicine at Mount Sinai, New
York, NY, United States
Three dimensional (3D) evaluation of atherosclerotic
plaque is important for investigating vascular disease.
Dynamic contrast enhanced (DCE) imaging is able to
measure the abundant microvasculature in vulnerable
plaque. However, it is challenging to achieve 3D
coverage and adequate temporal resolution, therefore, it
is important to optimize the available signal. Here, we
compare the signal weighting and contrast to noise ratio
of gradient-echo and spin-echo based 3D acquisition
sequences in a phantom and assess image quality pre and
post contrast agent administration in an atherosclerotic
rabbit model. The optimal sequence was a turbo field
echo acquisition with strong T1-weighting.
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