A new transducer-free MR elastography method for voxel-based mapping of aortic stiffness in vivo
Rachel Clough 1 , Jordi Alastruey 1 , Abdelali Ghazouani 1 , Louis Vilgrain 1 , Simon Lambert 1,2 , and Ralph Sinkus 1
Division of Imaging Sciences and Biomedical
Engineering, King's College London, London, London,
for Inflammation Research, INSERM U1149, Clichy, Ile de
Aortic stiffness is one of the most important risk
factors in the development of cardiovascular disease.
Magnetic resonance elastography (MRE) using an external
mechanical transducer has previously been used to
non-invasively assess the viscoelastic properties of
soft tissue by imaging the propagation of shear waves in
tissue. Here we develop a free-breathing MRE sequence
using shear waves generated by the aortic valve closure
(an intrinsic source of mechanical waves) to assess
aortic elasticity in vivo. Volunteer studies show a
clinically acceptable acquisition time (1:39(min:sec)),
and good correlation between MRE and pulse wave velocity
(the reference-standard) (bias=-0.26m/s).
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