Abstract #3932
Compartmentation in the Myocardium: On the Fate of Exogenous Versus Glycolytically Derived Pyruvate
Colin Purmal 1 , Blanka Kucejova 1 , Shawn Burgess 1 , Craig Malloy 1 , Dean Sherry 1 , and Matthew E Merritt 1
1
AIRC, UTSW Medical Center, Dallas, TX,
United States
Depending upon the underlying energetic demands for ATP
production in the myocardium, pyruvate has multiple
metabolic fates: exchanging with alanine or lactate,
being oxidized via the pyruvate dehydrogenase (PDH)
complex, or carboxylated to form oxaloacetate. Here the
metabolism of exogenous hyperpolarized [1-
13
C]pyruvate
is compared with that of glucose in the perfused mouse
heart. A battery of analyses indicate that 1)exogenous
pyruvate oxidation and glucose oxidation are not
synonymous, 2)hyperpolarized lactate production does not
necessarily report on [lactate] in the heart, and 3)
propionate activated PDH flux even in the presence of a
short chain fatty acid. The simplest interpretation of
these phenomena requires a two compartment model of
myocardial metabolism.
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