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Abstract #3962

Comparisons of Canine ECV Measurements by CMR at 3T: IR- vs. SR-based Cardiac T1 Mapping and Bolus Injection vs. Slow Infusion of Contrast Agent

Kyungpyo Hong 1,2 , Eugene G. Kholmovski 1 , Derek J. Dosdall 3 , Christopher J. McGann 3 , Ravi Ranjan 3 , and Daniel Kim 1

1 UCAIR, Department of Radiology, University of Utah, Salt Lake City, Utah, United States, 2 Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States, 3 CARMA, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States

While extracellular volume fraction (ECV) derived from hematocrit and pre- and post-contrast T1 measurements is an emerging method for assessment of diffuse cardiac fibrosis, systematic studies investigating the technical nuance are largely lacking. In well controlled canine experiment, we sought to compare ECV measurements between IR-based and SR-based cardiac T1 mapping pulse sequences, and ECV measurements between bolus injection and slow infusion protocols. Our results suggest that IR- and SR-based cardiac T1 mapping pulse sequences yield significantly different T1 and ECV measurements, and that 15 min after a bolus injection may not be dynamic equilibrium of contrast agent in canines.

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